Shakers

This article will look at the history and development of a de-facto standard in academic and industrial research laboratories throughput the world, the Multitron incubator shaker. The aim is to show that an initial revolution can lead to evolution, as needs change over time. The fundamentals of a good design can last decades, when new benefits and the best of current technologies are added regularly.

Humidification systems are vital for sucessful small-volume and long-lasting cultivations in the incubator shaker (e.g. screening in microtiter plates or cell culture). The different systems available on the market have one primary focus: to reduce evaporation losses by increasing the humidity levels inside the incubation chamber. However, there are significant differences in terms of quality, humidity control and sterility. This blog post highlights the Pros and Cons of the 3 most commonly used humidification systems.

In order to understand the optimum conditions for in-vitro culture, you need to know which natural environment gives the organism what they need to grow and thrive. In addition, a clear understanding of the different growth phases in a bioprocess is essential for selecting a bioprocess strategy.

In today’s world, bioprocess software solutions are an essential tool for modern laboratories. Bioprocesses are controlled using process data and optimized with the help of mathematical models based on the gathered data. Manual experiment planning and data documentation cannot keep up with this in the long term. Inefficiency, duplication of work, a lack of planning and poor or inconsistent data quality can have devastating consequences. If you want to have the quality, cost, and time-to-market of your products under control, it is essential to consistently digitize your bioprocesses – starting with the preculture in the incubator shaker.

Bioprocess development usually starts with screening for the most promising clones or culture conditions. All subsequent steps via process characterization, optimization, and finally, production are building on these first insights. Therefore, it is vital that the data generated during screening is of top quality.

The total quantity of biomass and its rate of growth are key parameters in most bioprocesses.  Both the measurement technology and method depend on the culture, the vessel and the type of organism.