Shakers

In order to understand the optimum conditions for in-vitro culture, you need to know which natural environment gives the organism what they need to grow and thrive. In addition, a clear understanding of the different growth phases in a bioprocess is essential for selecting a bioprocess strategy.

In today’s world, bioprocess software solutions are an essential tool for modern laboratories. Bioprocesses are controlled using process data and optimized with the help of mathematical models based on the gathered data. Manual experiment planning and data documentation cannot keep up with this in the long term. Inefficiency, duplication of work, a lack of planning and poor or inconsistent data quality can have devastating consequences. If you want to have the quality, cost, and time-to-market of your products under control, it is essential to consistently digitize your bioprocesses – starting with the preculture in the incubator shaker.

Bioprocess development usually starts with screening for the most promising clones or culture conditions. All subsequent steps via process characterization, optimization, and finally, production are building on these first insights. Therefore, it is vital that the data generated during screening is of top quality.

The total quantity of biomass and its rate of growth are key parameters in most bioprocesses.  Both the measurement technology and method depend on the culture, the vessel and the type of organism.

Getting started with cell culture can seem like an overwhelming step: cells are sensitive to shear stress, have a high risk of contamination and are very demanding concerning the right choice of process parameters. Check our blog post for all you need to start shaking or running your bioreactor with mammalian cells, insect cells and plant cells.

What is one of the worst things that could go wrong in your laboratory? Ask anyone working to a deadline in a bioprocess laboratory and a likely answer would be contamination of their cultures. Contamination can be hard to trace back to a source and difficult to remove if it is present in your working environment. Fortunately, there are a few simple steps you can follow to minimise the chances of this happening to you.