A truly universal bioreactor

Labfors 5

The Labfors 5 is suitable for cell cultures, microorganisms, phototrophic organisms as well as solid subtrates and enzymatic bioprocesses. There are almost no limits to its uses.

Labfors 5

High-end All-rounder
Up to six fully equipped bioreactors
4 pumps are standard
Optimum gassing with up to 5 gas lines

Optional

Application
Volume (TV)
Gassing
  • Air
  • CO2
  • N2
  • O2
Sensors
  • Biomass
  • Exit gas analysis (CO2, O2)
  • pCO2
  • Redox
  • Viable cell density
I am interested in:
  • Bioprocess Software
  • CIP/SIP
  • Qualification
Remarks

Configuration proposal
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Make six out of one

Would you like to organise your laboratory work more efficiently? Then connect your touchscreen control to up to six Labfors 5 devices. You can operate them simultaneously, and save time by, for example, calibrating all pH or pO2 sensors at the push of a button.

Fully equipped

An integrated analog feed pump is a standard feature that makes the bioreactor immediately ready for fed-batch cultures. The unit includes three digital pumps for acids, bases and antifoaming agents. Up to four gases (air, N2 , O2 and CO2 ) can be used in virtually any combination. Users can select either a mass-flow regulator or a rotameter for a precise feed. If required, additional sensors and actuators can be connected.

Automatic cleaning and sterilisation at the push of a button

At the push of a button, the LabCIP automatically cleans and sterilises the Labfors 5 bench-top bioreactor, for example over-night. The next day, your bioreactor is ready right away for your next microbial bioprocess. The throughput of experiments per bioreactor can be increased up to two-fold.

eve® Bioprocess Platform Software

eve® is able to do more than just plan, control and analyse your bioprocesses. The eve® software integrates workflows, devices, bioprocess information and big data in a web-based platform, with which you can organise your bioprocesses in a web based system.

Features

Culture vessels
  • Working volumes ranging between 0.5 and 10 L
  • Can be configured according to individual needs thanks to a selection of different stirrers, spargers and specialized accessories
  • Up to 14 ports for sensors (antifoam, optical density, pH, pO2, redox, conductivity, live cell density, etc.)
  • No welded lid components—ideal for GMP applications
  • High-performance pumps
  • Basic setup includes four precision pumps per culture vessel (option of one more)
  • Autoclavable pump heads
  • Gravimetric feeding (with external scale)
  • Profile-based pump-speed control with eve®
  • Gassing
  • Customer-specific gassing with up to 5 gas lines, either via a sparger or in the headspace
  • Feed via rotameter or mass-flow regulator
  • Cascades may be configured in serial or in parallel for controlling the pO2 via the stirrer speed, gassing rate, gas composition, etc.
  • pH control with acid and CO2
  • Sensors
  • Customers may choose from digital (Modbus) or analog sensors.
  • Product calibration of the pH sensor for reliable measurements during long-running bioprocesses
  • If required, additional sensors and actuators can be connected.
  • Cleaning and sterilisation
  • Automatic cleaning (CIP) and sterilisation (SIP) of all parts in contact with the product
  • Double throughput possible due to overnight cleaning
  • Reliable, reproducible and validatable base and/or acid cleaning
  • available as an option
  • LabCIP is patented (US Pat. No. 9,399,244; European patent No. 2 789 683).
  • Operating unit
  • Touchscreen with integrated OPC server
  • Reliable measurement and setting of the bioprocess parameters and communication with eve®
  • Parallel management and control of up to six devices
  • Up to 24 selectable parameters, such as temperature, stirring speed, pH, pO2, anti-foaming agent, feed
  • eve® Bioprocess Platform Software
  • Planning, controlling and analysing bioprocesses
  • Integrated workflows, devices and bioprocess knowledge
  • Integrates bioreactors and analytical instruments, regardless of the manufacturer
  • Web-based project organisation
  • Communication using the latest OPC UA (Minifors 2) or OPC-XML-DA standard (Multifors 2, Labfors 5, Techfors-S, Techfors)
  • Synchronisation of process-related events such as sampling or inoculation
  • Vessels 2 L / 3,6 L / 7,5 L / 10 L (cell version) / 13 L
    Working volume 0,5–1,2 L / 0,5–2,3 L / 1–5 L / 2,1–7 L (cell version) / 2,2–10 L
    Dimensions (W x D x H) 464 mm x 462 mm x 996 mm
    Drive Magnetic drive up to 300 min–1 (cell version); direct drive up to 1500 min–1
    Temperature Coolant temperature + 5 °C bis 70 °C bzw. 95 °C
    Gassing per vessel up to 5 rotameters or MFCs up to 2 min-1 (vvm) or 0.1 min-1 (cell version)
    Pumps per vessel 3 fixed, 1 variable, optional 1 additional variable 3
    Ports per vessel

      7 mm                max. 4x 
    10 mm                2x
    12 mm (Pg13,5) max. 6x
    19 mm                max. 6x

    Connectivity OPC XML DA via Ethernet
    Parallel operation via touch screen controller up to 6 vessels
    Sterilisation Autoclave or LabCIP (microbial version)
    Labfors 5
    Vessels 2 L / 3,6 L / 7,5 L / 10 L (cell version) / 13 L
    Working volume 0,5–1,2 L / 0,5–2,3 L / 1–5 L / 2,1–7 L (cell version) / 2,2–10 L
    Dimensions (W x D x H) 464 mm x 462 mm x 996 mm
    Drive Magnetic drive up to 300 min–1 (cell version); direct drive up to 1500 min–1
    Temperature Coolant temperature + 5 °C bis 70 °C bzw. 95 °C
    Gassing per vessel up to 5 rotameters or MFCs up to 2 min-1 (vvm) or 0.1 min-1 (cell version)
    Pumps per vessel 3 fixed, 1 variable, optional 1 additional variable 3
    Ports per vessel

      7 mm                max. 4x 
    10 mm                2x
    12 mm (Pg13,5) max. 6x
    19 mm                max. 6x

    Connectivity OPC XML DA via Ethernet
    Parallel operation via touch screen controller up to 6 vessels
    Sterilisation Autoclave or LabCIP (microbial version)
    We are thoroughly impressed by the practical design. It allows us to save time during calibration and preparation for cultivation.
    Mohd RazifMamat - Head Of Technical Administration & Operation, Malaysia Genome Institute

    «This bioreactor was developed in close collaboration with researchers. We have, therefore, achieved a level of optimization which meets the specific requirements for solid and enzymatic bioprocesses.»

    Simon Egli — Director Sales

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