Process development with phototrophic organisms

Uniform lighting for cultures plays a crucial role in developing processes with photosynthetically active organisms. In addition to low lighting intensity for initial characterization, this also means reliably generating high intensity light equivalent to sunlight. Precisely measuring and regulating light intensity is crucial for optimized processes with phototrophic organisms.

Scalable platform

Large flat-panel reactors are frequently used for large-scale production of high-quality products with phototrophic organisms under aseptic conditions. To ensure that a process can be readily transferred from the laboratory, one would ideally want to use a similar cultivation system on a laboratory scale. This should likewise include features such as a gentle, low-energy mixing process based on the airlift principle.

Light intensity: the central process parameter

The most important process parameter when culturing photosynthetically active organisms such as algae, plant cells and cyanobacteria is light intensity, which determines the growth rate, cell concentration and thus biomass productivity. Warm white light offers the ideal sunlight-like spectrum within the visible range, and contains a considerable proportion of photosynthetically active light.

Uniform light distribution is indispensable

In addition to light intensity, a successful process also depends on uniform light distribution within the culture. Optimizing the mixing process with respect to light distribution ensures that each cell will be exposed to the light source at brief intervals, and that all of the cells will therefore receive a reliable supply of light.

Simulating natural weather conditions

If process development is to mimic efficient, solar-powered outdoor production, variable weather conditions need to be taken into account as well. Modern process control accommodates infinitely variable light intensity adjustment and day/night cycle simulation.

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Our solutions for phototrophic process development

Multitron for phototrophic organisms

Multitron for phototrophic organisms

Sunlight in the shaker with excellent uniformity

  • Energy-saving, warm-white LED lighting

  • Light intensity up to 240 μmol m–2s–1

  • Even distribution of light across the tray

Labfors 5 photobioreactor

Labfors 5 photobioreactor

Flatbed-photobioreactor for process development

  • Autoclavable 1.9 L Flatbed culture vessel

  • LED lighting, intensity up to 3000 µmol m-2s-1

  • Comprehensive analysis options

eve®  – Bioprocess software for bioreactors

eve® – Bioprocess software for bioreactors

Workflow-oriented planning tools and comprehensive options for bioprocess control and monitoring

  • Location-independent monitoring and control of bioprocess parameters 

  • Detailed reporting according to GMP

  • Validation according to FDA 21 CFR Part 11

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The Labfors bioreactors, with their modular philosophy, give us enormous flexibility.
Prof. Dr. Christoph Herwig - Head of Biochemical Engineering, Vienna Technical University

«Infinitely variable light intensity control and day/night cycle simulation allow users to reproduce outdoor conditions in the laboratory.»

Iwo Zamora — Bioprocess Expert

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