Kontinuierliche Kultivierung mit Perfusion im Bioreaktor

The most important bioreactor for industrial applications is the conventional stirred tank reactor (STR), due to its high flexibility and low operating costs. Bioreactor purchases are often subjected to more scrutiny and debate than many other items of equipment of similar complexity and cost. The choice and sheer number of different systems can seem daunting. This article throws light upon the 4 major types of STR bioreactors used in bioprocess technology.

Design concept sketch by Meyer-Hayoz Design Engineering.

Continuous culture is best explained by discussing the basic components of the process. The theory is well known and simple to understand: Medium is both added and removed throughout much of the fermentation in order to keep cell numbers in balance. Actual execution can be difficult for starters, as there are more pumps, tubes and considerations than a simple batch fermentation.

Mammalian cell culture bioprocesses are increasingly gaining importance in the biopharmaceutical industry. Due to the high demand of product quality, the incubated shaker as a production unit can become a limiting factor after a certain point. Learn more and watch the webinar at the end of this post.