Publications

Product

03 oct. 2024
39 min read
Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development

Researchers at the University of Delaware used the INFORS HT Multitron incubator shaker to evaluate biolayer interferometry (BLI) for fast, high-throughput AAV capsid titer measurement. The study highlights the accuracy of AAVX-BLI across multiple rAAV serotypes, making it a strong alternative to ELISA. Applied in transfection optimization and AAV purification, this method offers valuable insights for improving rAAV production processes.

03 oct. 202439 min read
Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development

Researchers at the University of Delaware used the INFORS HT Multitron incubator shaker to evaluate biolayer interferometry (BLI) for fast, high-throughput AAV capsid titer measurement. The study highlights the accuracy of AAVX-BLI across multiple rAAV serotypes, making it a strong alternative to ELISA. Applied in transfection optimization and AAV purification, this method offers valuable insights for improving rAAV production processes.

03 oct. 202460 min read
Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

Researchers at Adimab, LLC isolated 188 monoclonal antibodies against Crimean-Congo hemorrhagic fever virus (CCHFV) GP38 from human survivors. While non-neutralizing, these antibodies target 11 overlapping sites and demonstrate protective efficacy in rodent models. This study provides valuable insights into CCHFV viral glycoprotein and could aid the development of antibody therapeutics for this lethal virus.

01 oct. 202442 min read
Chemoorganotrophic electrofermentation by Cupriavidus necator using redox mediators

Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.

01 oct. 202444 min read
Microbial production of 3-hydroxypropionic acid by acetic acid bacteria

Researchers at Université Paris-Saclay have developed a mathematical model that accurately predicts pH and metabolite concentrations during the microbial production of 3-hydroxypropionic acid using acetic acid bacteria. Using the INFORS HT Labfors bioreactor, the study focused on the bioconversion of 1,3-propanediol, taking into account the buffering capacity of the biological medium. Their model not only provided precise predictions of microbial growth and acid concentration but also serves as a critical tool for optimizing bioprocesses, particularly in scenarios with free pH dynamics. This work lays the foundation for future advancements in the production and in-situ extraction of organic acids.

01 oct. 202433 min read
Production and evaluation of a new set of recombinant antigens for the serological diagnosis of human cysticercosis

Researchers from the Department of Parasitology-Mycology at Institut Pasteur de Côte d'Ivoire are exploring new solutions for diagnosing human cysticercosis in remote areas. Their study tested a set of recombinant antigens for use in ELISA assays as a low-cost alternative to neuroimaging. While some challenges remain in optimizing sensitivity, the results show great promise, particularly in regions with limited medical resources. These antigens could provide a crucial screening tool for detecting neurocysticercosis, especially in patients with epilepsy, helping those in remote areas access better diagnosis and care.

27 sept. 202440 min read
Elucidating regulation of polyhydroxyalkanoate metabolism in Ralstonia eutropha

Researchers from Technische Universität Berlin have made significant progress in understanding the regulatory network behind polyhydroxyalkanoate (PHA) metabolism in Ralstonia eutropha. Their study, using the Multitron Standard incubator shaker, confirmed a key interaction involving transcription factor H16_B1672 and identified several other regulators that impact PHA synthesis. Despite challenges in fully characterizing all transcription factors, this research lays the groundwork for optimizing PHA production for industrial use, advancing sustainable bioplastic solutions.

23 sept. 202436 min read
Chlorella vulgaris cold preservation as a means to stabilize biomass for bioreactor inoculation: A six-month study

Researchers at Université Paris-Saclay explored efficient methods to preserve Chlorella vulgaris cells over six months with minimal maintenance. Their findings demonstrated that storing cells at 4C provided a stable, repeatable inoculum while reducing the need for frequent subculturing, compared to traditional maintenance methods. This approach allows for consistent experimental results and simplifies cell preservation in biotechnological applications. The research emphasizes the potential of low-temperature storage to streamline lab processes and reduce variability in microalgal studies.

23 sept. 202440 min read
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations

Researchers at Helmholtz-Centre for Environmental Research – UFZ GmbH, Leipzig, explored the effects of xenobiotics on gut microbiota using the Multifors bench-top bioreactor. Their findings highlight the impact of environmental contaminants like PFAS and BPX on microbial communities and metabolic pathways, emphasizing the need to consider these interactions for public health.

18 sept. 202446 min read
Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

Researchers from the University of Athens have successfully harnessed crude glycerol, a biodiesel by-product, as a substrate for producing valuable compounds like polyols and yeast biomass. Their study highlights the adaptability of wild-type Yarrowia lipolytica strains under low pH, low temperature, and non-aseptic conditions, offering a sustainable approach to bio-based production.

18 sept. 202445 min read
Insights into the relative contribution of four precursors to 3-sulfanylhexan-1-ol and 3-sulfanylhexylacetate biogenesis during fermentation

This study by researchers from the University of Auckland delves into the complex formation of 3-sulfanylhexan-1-ol (3SH) and 3-sulfanylhexyl acetate (3SHA), two essential contributors to white wine aroma. Using isotopically labeled analogues, the team uncovered how non-volatile precursors present in grapes convert to these key aroma compounds during fermentation. This research offers fresh insights into wine chemistry and the role of specific precursors in enhancing desirable wine aromas.

03 oct. 202460 min read
Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

Researchers at Adimab, LLC isolated 188 monoclonal antibodies against Crimean-Congo hemorrhagic fever virus (CCHFV) GP38 from human survivors. While non-neutralizing, these antibodies target 11 overlapping sites and demonstrate protective efficacy in rodent models. This study provides valuable insights into CCHFV viral glycoprotein and could aid the development of antibody therapeutics for this lethal virus.

01 oct. 202442 min read
Chemoorganotrophic electrofermentation by Cupriavidus necator using redox mediators

Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.

01 oct. 202444 min read
Microbial production of 3-hydroxypropionic acid by acetic acid bacteria

Researchers at Université Paris-Saclay have developed a mathematical model that accurately predicts pH and metabolite concentrations during the microbial production of 3-hydroxypropionic acid using acetic acid bacteria. Using the INFORS HT Labfors bioreactor, the study focused on the bioconversion of 1,3-propanediol, taking into account the buffering capacity of the biological medium. Their model not only provided precise predictions of microbial growth and acid concentration but also serves as a critical tool for optimizing bioprocesses, particularly in scenarios with free pH dynamics. This work lays the foundation for future advancements in the production and in-situ extraction of organic acids.

01 oct. 202433 min read
Production and evaluation of a new set of recombinant antigens for the serological diagnosis of human cysticercosis

Researchers from the Department of Parasitology-Mycology at Institut Pasteur de Côte d'Ivoire are exploring new solutions for diagnosing human cysticercosis in remote areas. Their study tested a set of recombinant antigens for use in ELISA assays as a low-cost alternative to neuroimaging. While some challenges remain in optimizing sensitivity, the results show great promise, particularly in regions with limited medical resources. These antigens could provide a crucial screening tool for detecting neurocysticercosis, especially in patients with epilepsy, helping those in remote areas access better diagnosis and care.

27 sept. 202440 min read
Elucidating regulation of polyhydroxyalkanoate metabolism in Ralstonia eutropha

Researchers from Technische Universität Berlin have made significant progress in understanding the regulatory network behind polyhydroxyalkanoate (PHA) metabolism in Ralstonia eutropha. Their study, using the Multitron Standard incubator shaker, confirmed a key interaction involving transcription factor H16_B1672 and identified several other regulators that impact PHA synthesis. Despite challenges in fully characterizing all transcription factors, this research lays the groundwork for optimizing PHA production for industrial use, advancing sustainable bioplastic solutions.

23 sept. 202436 min read
Chlorella vulgaris cold preservation as a means to stabilize biomass for bioreactor inoculation: A six-month study

Researchers at Université Paris-Saclay explored efficient methods to preserve Chlorella vulgaris cells over six months with minimal maintenance. Their findings demonstrated that storing cells at 4C provided a stable, repeatable inoculum while reducing the need for frequent subculturing, compared to traditional maintenance methods. This approach allows for consistent experimental results and simplifies cell preservation in biotechnological applications. The research emphasizes the potential of low-temperature storage to streamline lab processes and reduce variability in microalgal studies.

23 sept. 202440 min read
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations

Researchers at Helmholtz-Centre for Environmental Research – UFZ GmbH, Leipzig, explored the effects of xenobiotics on gut microbiota using the Multifors bench-top bioreactor. Their findings highlight the impact of environmental contaminants like PFAS and BPX on microbial communities and metabolic pathways, emphasizing the need to consider these interactions for public health.

18 sept. 202446 min read
Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

Researchers from the University of Athens have successfully harnessed crude glycerol, a biodiesel by-product, as a substrate for producing valuable compounds like polyols and yeast biomass. Their study highlights the adaptability of wild-type Yarrowia lipolytica strains under low pH, low temperature, and non-aseptic conditions, offering a sustainable approach to bio-based production.

18 sept. 202445 min read
Insights into the relative contribution of four precursors to 3-sulfanylhexan-1-ol and 3-sulfanylhexylacetate biogenesis during fermentation

This study by researchers from the University of Auckland delves into the complex formation of 3-sulfanylhexan-1-ol (3SH) and 3-sulfanylhexyl acetate (3SHA), two essential contributors to white wine aroma. Using isotopically labeled analogues, the team uncovered how non-volatile precursors present in grapes convert to these key aroma compounds during fermentation. This research offers fresh insights into wine chemistry and the role of specific precursors in enhancing desirable wine aromas.

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