Automated feeding of liquids in shake flasks

LIS - Liquid Injection System

LIS is the first easy-to-use technology allowing for automatic, parallelized and uncomplicated feeding of liquids in shake flasks. The systems consists of three components: the drive, the cartridge and optionally the software. Various predefined feeding profiles allow users to quickly create individual feeding strategies for their shake flask cultures. By using the LIS software, experiments can be monitored and controlled wirelessly. Additionally, it allows you to configure indivisual feeding profiles. LIS is compatible with various substances such as sugars, alcohols as well as acids or bases.

LIS - Liquid Injection System

For fed-batch experiments in shake flask cultivations

Suitable for bacteria, algae and cell cultures

Compatible with all types of laboratory shakers and various substances

Customizable feeding profiles

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LIS - Liquid Injection System
For fed-batch experiments in shake flask cultivations

Compatible with all types of laboratory shakers

LIS is compatible with all types of laboratory shakers, spring clamps and Sticky Stuff, as well as all 38 mm straight neck glass and plastic flasks.

Wireless montoring and control

Control and monitor your feeding process via the LIS software and the bioprocess platform eve^®.

Can be used for a diverse range of scientific applications

e.g. Fed-batch experiments, passive pH control, automatic induction of protein expression, toxicity tests, phage assays, co-cultures

Features

Cartridge	The cartridge is a sterile single us container with the shape of a lid. It fits on all shake flasks that are normally sealed with a metal cap and can be filled with up to 25 mL of the feeding liquid.
Drive	The drive is a programmable miniature pump that controls when and how much liquid is fed from the cartridge into the flask. You can either program the feeding profile in the drive manually using the knob on top of the drive or wirelessly by using the LIS software.
eve® platform software for your bioprocesses	With eve^® the LIS pump can be controlled remotely and complex feeding strategies such as exponential feeding or time/event-based feeding strategies can easily be configured. The values are monitored along other bioprocess parameters and saved in a central database.

Technical Details

Drive	Input voltage: 5 CDC +/- 5 % Input current: min. 200 mA
Cartridge	Sterilization: Ethylene Oxide Fitting flask type: straight neck (no brim) Fitting flask outside diameter: 38 mm (+/- 0,3 mm); fitting flask minimum inside diameter: 33 mm
Pump flow rate	max. 1 ml/min
Battery	Type: Li-Ion Capacity: 600 mAh Run time: ca. 1 week depending on feeding profile Charging time: ca 2 hours Charging source: USB 2.0 Port
Dimensions	height (with mounting ring) ca. 88 mm; additional height on shake flask: ca. 70 mm
Rotation speed	200 min^-1 - 300 min^-1 depending on shaking throw and shake flask size
Shake flask sizes	100 ml 250 ml 300 ml 500 ml 1000 ml 2000 ml
Temperature	10 – 45 °C
Ambient humidity (rH)	Relative humidity: 0 – 80% (not-condensing)
System requirements	CPU: min. dual core 2 CHz RAM / HDD: ≥4 GB / ≥10 GB Operating system: Microsoft Windows 7 or newer with JRE 8 and .NET 4.5 Screen resolution: 1920 x 1080 pixels Recommended Web browser: Firefox, Chrome

Downloads

Flyer & Brochures

Flyer LIS (267.3 kB)

INFORS HT - Our Products (2.2 MB)

LIS FAQ (583.3 kB)

Manuals

LIS User Guide (1.7 MB)

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White Papers

Automated Liquid Addition in Shake Flasks (1.1 MB)

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	LIS - Liquid Injection System
Drive	Input voltage: 5 CDC +/- 5 % Input current: min. 200 mA
Cartridge	Sterilization: Ethylene Oxide Fitting flask type: straight neck (no brim) Fitting flask outside diameter: 38 mm (+/- 0,3 mm); fitting flask minimum inside diameter: 33 mm
Pump flow rate	max. 1 ml/min
Battery	Type: Li-Ion Capacity: 600 mAh Run time: ca. 1 week depending on feeding profile Charging time: ca 2 hours Charging source: USB 2.0 Port
Dimensions	height (with mounting ring) ca. 88 mm; additional height on shake flask: ca. 70 mm	Holder for long test tubes: 342 mm x 60-125 mm (W x H) Holder for short test tubes: 342 mm x 45-75 mm (W x H)	465 x 280 mm			All trays are designed for plates with external dimensions of 85.5 x 127.5 mm. Deep-well plates 42 mm high, 3 mm base height
Rotation speed	200 min^-1 - 300 min^-1 depending on shaking throw and shake flask size		Universal tray: 250 min^-1 (25 mm shaking throw) Sticky Stuff tray: 200 min^-1 (25 mm shaking throw) Sticky Stuff tray: 150 min^-1 (50 mm shaking throw)					150 - 350 min^-1 (clamps) 0 - 200 min^-1 (StickyStuff)
Shake flask sizes	100 ml 250 ml 300 ml 500 ml 1000 ml 2000 ml							100 mL 250 mL 500 mL 1000 mL 2000 mL 5000 mL
Temperature	10 – 45 °C							10 - 50 °C
Ambient humidity (rH)	Relative humidity: 0 – 80% (not-condensing)							0 - 80% (non-condensing)
System requirements	CPU: min. dual core 2 CHz RAM / HDD: ≥4 GB / ≥10 GB Operating system: Microsoft Windows 7 or newer with JRE 8 and .NET 4.5 Screen resolution: 1920 x 1080 pixels Recommended Web browser: Firefox, Chrome							Windows 7 or newer with .NET 4.7; Dual Core @ 2 GHz/core; >8 GB RAM; >10 GB HDD
		Go to Test tube holder for shakers	Go to Box for Microtiter Plates	Go to Universal trays	Go to Fixed-configuration trays	Go to Trays for microtiter plates and deep-well plates	Go to Sticky Stuff	Go to CGQ - Cell Growth Quantifier	Go to Celltron	Go to Orbitron	Go to Multitron	Go to Minitron	Go to Ecotron	Go to Multitron Standard	Go to Ecotron	Go to Minitron	Go to Multitron	Go to Multitron Standard

Automated Liquid Addition in Shake Flasks

In this White Paper we show the features of liquids feeding for highly automated and parallelized bioprocess control. This opens the way of efficient applications relared to DoE.

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