6/11/2019 New release of eve®, the bioprocess platform software

INFORS HT is releasing a new, even more powerful version of eve®. It includes better integration with hardware and software from third-party suppliers. Furthermore, a new alarm function is now available. This alerts the user via email if there are errors or values which deviate during the bioprocess.

The latest eve® version, Q2 2019, makes it even easier to integrate devices and software from third-party manufacturers into the platform. The new email alarm goes beyond the previous control and monitoring via the browser. It notifies the user as soon as an alarm occurs in a specific batch. The parameters for this alarm, such as temperature deviations or network problems, can be specified in advance for each batch. Here is an overview of the most important features of the new eve® version: 

  • New automatic email alarm system: eve® sends you emails in the case of batch alarms
  • Increased compatibility and flexibility with 3rd party devices and software: New REST API and new user interface for drivers to easily and quickly integrate additional devices and software to eve® 
  • The LIS (Liquid Injection System) shake flask feed pumps from aquila biolabs is now supported by eve®

Additional features and optimizations:

  • Improved overall performance when opening batches
  • Automatic notification when a new version becomes available
  • New SI units for parameters are available
  • Designation of user-specified functions in the batch strategy
  • Parameters can be renamed to allow adoption of the name(s) used by the connected device
  • Customizable OPC (DA, XML DA and UA) drivers with new user interface
  • Customizable Modbus (RTU and TCP) driver with new user interface
  • Customizable Applikon drivers with new user interface

The new version is available for free download to users with a valid Support & Assurance license.

5/17/2019 Biomass measurement in bioreactors is becoming even simpler and more comprehensive

With the combination of two new products, INFORS HT and aquila biolabs provide a new solution for the automatic, comprehensive and yet straightforward biomass measurement in bioreactors. This is possible with the technology of non-invasive online measurement of biomass which is integrated in the eve® platform software for bioprocesses.

A manual offline biomass measurement is time-consuming, allows only a limited understanding of the bioprocess, and entails a higher rate of error. Because sensors are used, there is no need for manual samples for biomass measurement. aquila biolabs goes one step further and it offers a sensor – the CGQ BioR – which does not even need to be introduced into the culture medium. Instead, the sensor is mounted on the outer wall of the culture vessel and measures the biomass optically using scattered light measurements. In this way, detailed microbial growth kinetics are recorded in real time. At the same time, autoclaving and installation are eliminated beforehand – the sensor can be mounted at any time. The biomass data provided by the CGQ BioR can be used for process control, for example, in the growth-curve-based induction of protein production or to generate feeding profiles. If the data are transferred into eve®, the growth kinetics can be clearly documented and compared with earlier batches. The event-based control is thus just as easy as complex feeding profiles based on the biomass development. In addition, eve® provides a soft sensor for correlating the measured values with, for example, OD or bio dry mass. The CGQ BioR can be directly integrated into INFORS HT bioreactors. The measured values are displayed directly on their touch screens. Alternatively the sensor is available as a stand-alone version for the devices from third-party suppliers.

5/6/2019 Minifors 2 bench-top bioreactor now also for cell cultures

INFORS HT expands the product portfolio for cell culture applications. The Minifors 2 bench-top bioreactor, which won the iF Gold Award for its user-friendly design, is now available in a new version. The proven concept – a compact bioreactor system which has comprehensive features and is easy to operate – remains the same.

The Minifors 2 is a preconfigured complete package with which users can quickly start their cell culture processes without time-consuming installation. The culture vessel, which is available in three sizes, is fully equipped with a digital pH sensor and optical pO2 sensor, temperature sensor, exhaust gas cooler, (anti-)foam sensor, sparger, sampling system and up to three additional freely available ports. The culture vessel is operated on a compact base unit with four freely configurable pumps and a touch screen as the operating unit. The cell culture version additionally offers five fully automatic gas lines and can additionally control external pumps via two analogue inputs and outputs. In addition, the bioreactor can be optionally expanded by biomass sensors, exhaust gas analysis and an external scale for gravimetric feeding. With these additional options and the connection to the eve® platform software, bioprocesses can be understood even more easily and optimized further. Thanks to the integrated and intuitive touch screen software, the Minifors 2 remains easy to operate, despite the comprehensive features. The intuitive software provides multilingual step-by-step guidance through all functions, such as calibration of the sensors. If needed, brief texts with information on components and applications can be displayed. “Especially for beginners who need a ready-to-use and easy-to-handle bioreactor for their cell culture applications, we consider the Minifors 2 for cell cultures to be an interesting alternative to single-use bioreactors,” says Daniel Egger, marketing director at INFORS HT.  

1/17/2019 The best Multitron of all time

A new chapter in an ongoing success story: over 20 years after the Multitron was first introduced on the market, INFORS HT now presents its fourth-generation, redesigned incubation shaker—one representing a new, even better solution for ideal cultivation conditions and delivering unsurpassed capacity, a minimal footprint and easy operation.

The new Multitron offers researchers even better conditions for cultivating microorganisms, cell cultures and phototropic organisms. The new temperature-control concept allows users to achieve optimum, gradient-free temperature uniformity, guaranteeing comparable growth conditions across all batches. The hygienic design of the new Multitron has been improved as well, with rounded interior corners for a chamber that has fewer components, making it far easier to clean. And its new UV decontamination feature, its condensate-free, direct-steam humidification, and its antibacterial coating for the housing mean that the Multitron meets the stringent requirements of cell-culture applications.

The new Multitron also satisfies the increasing efficiency demands of the biotech industry. As was the case with its predecessor, the capacity-to-footprint ratio of this incubation shaker is unlike any other: by using a three-tier stacked configuration, researchers can cultivate over 50 liters and/or 23,000 batches in parallel—even though the base is only 1 m wide. The top unit remains at a comfortable working height of 1.40 m, while the new door mechanism and quick, automated start-stop feature keep interruptions in the cultivation process to a minimum.

“By combining traditional advantages with new features, the new Multitron is a response to trends and to new demands in research and development—developments that include increasing digitalization. Starting now, for example, the Multitron comes with an Ethernet interface that can be used for connecting to simple SCADA software such as eve®,” explains Dr. Dirk Hebel, bioprocess equipment product manager for INFORS HT. Customers can place their orders for the new Multitron with any INFORS HT affiliate or distributor beginning January 18.

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