For sophisticated cell culture bioprocesses on a small scale

Multifors 2 for cell culture

With Multifors 2 you can work with up to six bioprocesses in parallel. The cell version comes available with a gentle stirring system and an optional round-bottom vessel, making it suitable for suspension cultures and adherent cells on microcarriers.

Multifors 2 for cell culture

Big technology on a small scale
4 high-performance pumps
4 high-performance pumps
Optimum gassing with up to 5 gas lines
Up to six fully equipped bioreactors

Optional

No. of bioreactors
Volume (TV)
Gassing
  • Air
  • O2
  • N2
  • CO2
Sensors
  • Biomass
  • Exit gas analysis (CO2, O2)
  • pCO2
  • Redox
  • Viable cell density
I am interested in:
  • Sterile Sampling
  • Perfusion
  • Bioprocess Software
  • Qualification

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Multifors 2 for cell culture
Big technology on a small scale

Determining the live cell density

Track the condition of your cells in real time—without taking any samples at all—and understand your bioprocesses better. Thanks to comprehensive control features offered by the touchscreen and by our eve® bioprocess software, you can also develop sophisticated, automated control strategies.

Make six out of one

Would you like to organise your laboratory work more efficiently? Then connect your touchscreen control to up to six Labfors 5 devices. You can operate them simultaneously, and save time by, for example, calibrating all pH or pO2 sensors at the push of a button.

Fully equipped

An integrated analog feed pump is a standard feature that makes the bioreactor immediately ready for fed-batch cultures. The unit includes three digital pumps for acids, bases and antifoaming agents. Up to four gases (air, N2 , O2 and CO2 ) can be used in virtually any combination. Users can select either a mass-flow regulator or a rotameter for a precise feed. If required, additional sensors and actuators can be connected.

Developed for scale-up and scale-down

The Multifors 2 offers you fully functional bioreactors on a small scale, employing the same sensor technologies as larger bioreactors and consequently delivering directly comparable data. Optional PAT tools offer you a simple way of preparing for later production in a benchtop or pilot-plant reactor.

Features

Culture vessels
  • Culture vessels are easy to exchange
  • Powerful magnetic drive
  • Magnetic coupling reduces the risk of contamination and simplifies handling
  • Specialized stirring systems for microorganisms and cell cultures
  • Top plate
  • Motor underneath the vessel for excellent accessibility to available ports
  • Up to 13 ports for sensors (antifoam, optical density, pH, pO2, redox, conductivity, live cell density, etc.)
  • High-performance pumps
  • Basic setup includes four precision pumps per culture vessel (option of one more)
  • Autoclavable pump heads
  • Gravimetric feeding (with external scale)
  • Profile-based pump-speed control with eve®
  • Gassing
  • Customer-specific gassing with up to 5 gas lines, either via a sparger or in the headspace
  • Feed via rotameter or mass-flow regulator
  • Cascades may be configured in serial or in parallel for controlling the pO2 via the stirrer speed, gassing rate, gas composition, etc.
  • pH control with acid and CO2
  • Sensors
  • Customers may choose from digital (Modbus) or analog sensors.
  • Product calibration of the pH sensor for reliable measurements during long-running bioprocesses
  • If required, additional sensors and actuators can be connected.
  • Operating unit
  • Touchscreen with integrated OPC server
  • Reliable measurement and setting of the bioprocess parameters and communication with eve®
  • Parallel management and control of up to six devices
  • Up to 24 selectable parameters, such as temperature, stirring speed, pH, pO2, anti-foaming agent, feed
  • eve® Bioprocess Platform Software
  • Planning, controlling and analysing bioprocesses
  • Integrated workflows, devices and bioprocess knowledge
  • Integrates bioreactors and analytical instruments, regardless of the manufacturer
  • Web-based project organisation
  • Communication using the latest OPC UA (Minifors 2) or OPC XML-DA standard (Multifors 2, Labfors 5, Techfors-S, Techfors)
  • Synchronisation of process-related events such as sampling or inoculation
  • Vessels 0,4 L / 0,7 l / 1,0 L
    Working volume 0,097–0,025 L / 0,15–0,5 L / 0,22–0,75 L
    Dimensions (W x D x H) 350 mm x 520 mm x 960 mm
    Drive Magnetic drive to 300 min-1
    Temperature Coolant temperature + 5 °C to 70 °C
    Gassing per vessel Up to 4 rotameters oder MFCs up to 0,1 min-1 (vvm)
    Pumps per vessel 3 fixed, 1 variable, optional 1 additional variable
    Ports per vessel

    7 mm                   4x
    10 mm                 4x
    12 mm (Pg13,5)  max. 5x

    Connectivity OPC XML DA via Ethernet
    Parallel operation via touch screen controller 3 base units, resp. 6 vessels
    Sterilisation Autoclave

    Manuals

    Brief Instructions Super Safe Sampler (681.5 kB)

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    Operating manual Gas Analyser (1.4 MB)

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    Operating manual Multifors 2 (7.4 MB)

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    Operating manual Touchscreen Software V 3.0 (3.6 MB)

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    White Papers

    Continuous Culture as the Universal Bioprocess for Manufacturing (934.8 kB)

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    Multifors 2 for cell culture
    Vessels 0,4 L / 0,7 l / 1,0 L
    Working volume 0,097–0,025 L / 0,15–0,5 L / 0,22–0,75 L
    Dimensions (W x D x H) 350 mm x 520 mm x 960 mm
    Drive Magnetic drive to 300 min-1
    Temperature Coolant temperature + 5 °C to 70 °C
    Gassing per vessel Up to 4 rotameters oder MFCs up to 0,1 min-1 (vvm)
    Pumps per vessel 3 fixed, 1 variable, optional 1 additional variable
    Ports per vessel

    7 mm                   4x
    10 mm                 4x
    12 mm (Pg13,5)  max. 5x

    Connectivity OPC XML DA via Ethernet
    Parallel operation via touch screen controller 3 base units, resp. 6 vessels
    Sterilisation Autoclave
    The option to run up to six units from a simple control unit creates a small bench foot print and makes experimental design simple and efficient.
    Dr. Emma Allen-Vercoe - Associate Professor, University of Guelph, Canada

    «With Multifors 2, we have optimized the simple and safe operation of many bioreactors at the same time. This saves a lot of time and makes efficient parallel bioprocessing possible.»

    Daniel Egger — Director Marketing & Software Development

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