Protein production with cell cultures

Labfors 5 for cell culture

The Labfors 5 is ideal for cell culture. The bioreactor has a gentle magnetic stirring system, precise gas supply via mass flow controllers and is easy to clean. Numerous sensors in combination with the bioprocess software eve ® ensure precise control and monitoring of the bioprocess.

Labfors 5 for cell culture

Optimum conditions for mammalian and insect cells
Gentle magnetic stirring system capable of reaching up to 300 min–1
4 high-performance pumps
Optimum gassing with up to 5 gas lines
Up to six fully equipped bioreactors

Optional

Volumen (TV)
Gassing
  • Air
  • O2
  • N2
  • CO2
Sensoren
  • Biomass
  • Exit Gas (CO2, O2)
  • Live Cell Density
  • pCO2
  • Redox
I am interested in:
  • Single-use vessels
  • Sterile Sampling
  • Perfusion
  • Bioprocess software
  • Qualification

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Labfors 5 for cell culture
Optimum conditions for mammalian and insect cells

Glass or single-use? – Both!

Stay flexible. Our single-use option lets you switch between glass and disposable culture vessels in just 2 steps, without compromising the sensors.

Fully equipped

An integrated analog feed pump is a standard feature that makes the bioreactor immediately ready for fed-batch cultures. The unit includes three digital pumps for acids, bases and antifoaming agents. Up to four gases (air, N2 , O2 and CO2 ) can be used in virtually any combination. Users can select either a mass-flow regulator or a rotameter for a precise feed. If required, additional sensors and actuators can be connected.

Make six out of one

Would you like to organise your laboratory work more efficiently? Then connect your touchscreen control to up to six Labfors 5 devices. You can operate them simultaneously, and save time by, for example, calibrating all pH or pO2 sensors at the push of a button.

Features

Culture vessels
  • Working volumes ranging between 0.5 and 10 L
  • Can be configured according to individual needs thanks to a selection of different stirrers, spargers and specialized accessories
  • Up to 14 ports for sensors (antifoam, optical density, pH, pO2, redox, conductivity, live cell density, etc.)
  • No welded lid components—ideal for GMP applications
  • Mobius® 3L Single-use Bioreactor
  • Working volume between 0.9 L and 2.4 L
  • Switch between glass and disposable culture vessels in just two steps
  • High-performance pumps
  • Basic setup includes four precision pumps per culture vessel (option of one more)
  • Autoclavable pump heads
  • Gravimetric feeding (with external scale)
  • Profile-based pump-speed control with eve®
  • Gassing
  • Customer-specific gassing with up to 5 gas lines, either via a sparger or in the headspace
  • Feed via rotameter or mass-flow regulator
  • Cascades may be configured in serial or in parallel for controlling the pO2 via the stirrer speed, gassing rate, gas composition, etc.
  • pH control with acid and CO2
  • Sensors
  • Customers may choose from digital (Modbus) or analog sensors.
  • Product calibration of the pH sensor for reliable measurements during long-running bioprocesses
  • If required, additional sensors and actuators can be connected.
  • Operating unit
  • Touchscreen with integrated OPC server
  • Reliable measurement and setting of the bioprocess parameters and communication with eve®
  • Parallel management and control of up to six devices
  • Up to 24 selectable parameters, such as temperature, stirring speed, pH, pO2, anti-foaming agent, feed
  • eve® Bioprocess Platform Software
  • Planning, controlling and analysing bioprocesses
  • Integrated workflows, devices and bioprocess knowledge
  • Integrates bioreactors and analytical instruments, regardless of the manufacturer
  • Web-based project organisation
  • Communication using the latest OPC UA (Minifors 2) or OPC XML-DA standard (Multifors 2, Labfors 5, Techfors-S, Techfors)
  • Synchronisation of process-related events such as sampling or inoculation
  • Vessels 2 L / 3,6 L / 7,5 L / 10 L / 13 L
    Working volume 0,5–1,2 L / 0,5–2,3 L / 1–5 L / 2,1–7 L / 2,2–10 L
    Dimensions (W x D x H) 464 mm x 462 mm x 996 mm
    Drive Magnetic drive up to 300 min–1
    Temperature Coolant temperature + 5 °C to 70 °C or 95 °C
    Gassing per vessel up to 5 MFCs up to 0.1 min-1
    Pumps per vessel 3 fixed, 1 variable, optional 2 additional variable
    Ports per vessel 7 mm: max. 4x
    10 mm: 2x
    12 mm (Pg13,5): max. 6x
    19 mm: max 6x
    Connectivity OPC XML DA via Ethernet
    Parallel operation via touch screen controller up to 6 vessels
    Sterilisation Autoclave

    Application Notes

    Manuals

    Brief Instructions Super Safe Sampler (681.5 kB)

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    Operating manual Gas Analyser (1.4 MB)

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    Operating manual Labfors 5 version for cell cultures (8.5 MB)

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    Operating manual Labfors 5 version for cell cultures - Single use (427.7 kB)

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    Operating manual Touchscreen Software V 3.0 (3.6 MB)

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    White Papers

    White Paper (934.8 kB)

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    Labfors 5 for cell culture
    Vessels 2 L / 3,6 L / 7,5 L / 10 L / 13 L
    Working volume 0,5–1,2 L / 0,5–2,3 L / 1–5 L / 2,1–7 L / 2,2–10 L
    Dimensions (W x D x H) 464 mm x 462 mm x 996 mm
    Drive Magnetic drive up to 300 min–1
    Temperature Coolant temperature + 5 °C to 70 °C or 95 °C
    Gassing per vessel up to 5 MFCs up to 0.1 min-1
    Pumps per vessel 3 fixed, 1 variable, optional 2 additional variable
    Ports per vessel 7 mm: max. 4x
    10 mm: 2x
    12 mm (Pg13,5): max. 6x
    19 mm: max 6x
    Connectivity OPC XML DA via Ethernet
    Parallel operation via touch screen controller up to 6 vessels
    Sterilisation Autoclave
    The Labfors bioreactors, with their modular philosophy, give us enormous flexibility.
    Prof. Dr. Christoph Herwig - Head of Biochemical Engineering, Vienna Technical University

    «Our most versatile and freely configurable benchtop bioreactor, which can handle even the most complex PAT applications.»

    Eric Abellan — Product Manager Software

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