Enzymatic hydrolysis and fermentation combined in one system (SSF)

Labfors 5 for solid substrates and enzymatic bioprocesses

The bioreactor for a variety of enzymatic hydrolysis and fermentation types. Equipped with a very powerful motor for optimum mixing, even if the viscosity is high or the starting material contains a large amount of dry matter.

Labfors 5 for solid substrates and enzymatic bioprocesses

The bioreactor for a variety of enzymatic hydrolysis and fermentation types.
Autoclavable 3.9 L vessel
Special stirrer types for solid substrates
Autoclavable 3.9 L vessel
Large port for substrate addition

Optional

I am interested in:
  • Exit gas analysis
  • Bioprocess software
  • Sensor protection
  • SSF-optimized sparger
Remarks

Configuration proposal
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Ideal mixing

Viscous liquid? Solids? Because liquids and solids have different mixing properties, we offer you a selection of stirrers for the right stirring system no matter what the substrate.

Precise, gentle temperature control for sensitive, solids-containing media

By regulating the temperature of both the substrate and the double mantle, the two-fold system optimizes temperature control for the entire bioprocess. This prevents overheating along the interior vessel wall, keeping enzymatic activity high.

Analyzing the hydrolysis process

Recording motor torque in real time makes it possible to draw conclusions regarding viscosity and, in turn, the progress of solids fermentation. Whereas the viscosity of the solids-containing substrate is initially high, enzymatic hydrolysis will cause it to drop continuously until the medium is liquid. This, for instance, allows researchers to determine the optimum time for introducing the yeast and beginning fermentation.

Features

Culture vessels
  • Working volumes ranging between 1 and 2.5 L
  • Can be configured according to individual needs thanks to a selection of different stirrers, spargers and specialized accessories
  • Up to 9 ports for sensors (antifoam, optical density, pH, pO2, redox, conductivity, live cell density, etc.)
  • Protective sleeve for the glass pH sensor
  • A 40 mm port makes it easy to introduce solids
  • No welded lid components—ideal for GMP applications
  • High-performance pumps
  • Basic setup includes four precision pumps per culture vessel (option of one more)
  • Autoclavable pump heads
  • Gravimetric feeding (with external scale)
  • Profile-based pump-speed control with eve®
  • Gassing
  • Customer-specific gassing with up to 5 gas lines, either via a sparger or in the headspace
  • Feed via rotameter or mass-flow regulator
  • Cascades may be configured in serial or in parallel for controlling the pO2 via the stirrer speed, gassing rate, gas composition, etc.
  • pH control with acid and CO2
  • Sensors
  • Customers may choose from digital (Modbus) or analog sensors.
  • Product calibration of the pH sensor for reliable measurements during long-running bioprocesses
  • If required, additional sensors and actuators can be connected.
  • Operating unit
  • Touchscreen with integrated OPC server
  • Reliable measurement and setting of the bioprocess parameters and communication with eve®
  • Parallel management and control of up to six devices
  • Up to 24 selectable parameters, such as temperature, stirring speed, pH, pO2, anti-foaming agent, feed
  • eve® Bioprocess Platform Software
  • Planning, controlling and analysing bioprocesses
  • Integrated workflows, devices and bioprocess knowledge
  • Integrates bioreactors and analytical instruments, regardless of the manufacturer
  • Web-based project organisation
  • Communication using the latest OPC UA (Minifors 2) or OPC XML-DA standard (Multifors 2, Labfors 5, Techfors-S, Techfors)
  • Synchronisation of process-related events such as sampling or inoculation
  • Vessels 3,9 L
    Working volume 1–2,5 L
    Dimensions (W x D x H) 515 mm x 515 mm x 1050 mm
    Drive Direct drive up to 1000 min-1
    Temperature coolant temperature + 5 °C bis 70 °C
    Gassing per vessel 5 MFCs 2 min–1 (vvm)
    Pumps per vessel 3 fixed, 1 variable, optional 2 additional variable
    Connectivity OPC XML DA via Ethernet
    Parallel operation via touch screen controller up to 6 vessels
    Sterilisation Autoclave
    Labfors 5 for solid substrates and enzymatic bioprocesses
    Vessels 3,9 L
    Working volume 1–2,5 L
    Dimensions (W x D x H) 515 mm x 515 mm x 1050 mm
    Drive Direct drive up to 1000 min-1
    Temperature coolant temperature + 5 °C bis 70 °C
    Gassing per vessel 5 MFCs 2 min–1 (vvm)
    Pumps per vessel 3 fixed, 1 variable, optional 2 additional variable
    Connectivity OPC XML DA via Ethernet
    Parallel operation via touch screen controller up to 6 vessels
    Sterilisation Autoclave
    The Labfors bioreactors, with their modular philosophy, give us enormous flexibility.
    Prof. Dr. Christoph Herwig - Head of Biochemical Engineering, Vienna Technical University

    «This bioreactor was developed in close collaboration with researchers. We have, therefore, achieved a level of optimization which meets the specific requirements for solid and enzymatic bioprocesses.»

    Simon Egli — Director Sales

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